With Merck’s oral PCSK9 inhibitor demonstrating strong phase 3 trial results, J&J’s IL23R antagonist peptide continuing its phase 3 journey, and Chugai advancing peptides into the intracellular space, peptide therapeutics are firmly back on the map as the next modality disrupting drug discovery and development. This includes exploring peptide structure prediction using AI/ML technologies, designing orally bioavailable and cell membrane-permeable peptides using structure-based molecular design, harnessing mRNA display and DNA-encoded libraries for peptide discovery, optimizing peptide synthesis, integrating formulation considerations at the discovery stage, and investigating peptides as drug delivery vehicles.